Professor John Stamatoyannopoulos
Dr. Stamatoyannopoulos' laboratory focuses on how the human genome encodes transcriptional regulatory programs that unfold during development and differentiation, and how defects in these programs underlie common diseases.
Ongoing efforts in the Stamatoyannopoulos lab:
- To understand how and where regulatory information is encoded within the human genome, from individual nucleotides to genome-scale patterns of regulatory DNA activation
- To define and analyze transcription factor regulatory networks
- To map and determine the functional consequences of disease-associated non-coding variation in regulatory DNA
- To define the genomic regulatory mechanisms underlying the genesis and perpetuation of cancer
- To create next-generation technologies for visualizing and analyzing the living regulatory genome